Teenage Mutant Ninja Turtlesfans emerged at Comic-Con International: San Diego 2018 for Nickelodeon’sRise of the Teenage Mutant Ninja Turtlespanel where the new voice cast–Omar Milleras Raph,Ben Schwartzas Leo,Josh Breneras Donnie,Brandon Mychal Smithas Mikey,Kat Grahamas April O’Neil, andEric Bauzaas Splinter–along with the co-executive producersAndy SurianoandAnt Ward, and legendary voice directorRob Paulsenshared what to expect in the latest incarnation ofTurtles, a reinvention of the world-famous franchise. Moderated byKeely Flahertyof BuzzFeed, the panel included behind-the-scenes reveals, a brand-new trailer, and never-before-seen clips from the upcoming series.

Raph, Leo, Donnie and Mikey emerge from the sewers and tap into undiscovered ninja powers in Nickelodeon’s reimagined, 2D-animated seriesRise of the Teenage Mutant Ninja Turtles, debutingMonday, September 17th. The action-comedy series follows the band of brothers as they discover new powers and encounter a mystical world they never knew existed beneath the streets of New York City. In the months following, the series will premiere globally across Nickelodeon’s channels and branded blocks in 170+ countries and territories.

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Take a look at the brand-new trailer below, followed by an exclusive quote from super-villainous guest starRhys Darbyand a new look at the villains ofRise of Teenage Mutant Ninja Turtlesin our gallery:

Here’s what Darby had to say:

“As a kid I would run home from school to watch the greatest cartoon in the world. I can’t believe that little ole me is now part of the TMNT universe. Finally, the magical kiwi hippo gets his day in the sun. What a pleasure it is to play him on TMNT! I’ve been telling people that New Zealand has magical hippos for years, maybe now you’ll all start taking me seriously!”

Rise of the Teenage Mutant Ninja Turtlesfollows the Turtles on all-new adventures as they master new powers, encounter absurd mutants and battle bizarre villains, each with their own motivations. Ranging from mystics, mutants and madmen, new creatures and villains emerge to take on Raph, Leo, Donnie and Mikey in battles across New York City.  From the tallest skyscraper to the dankest sewer drain, the brothers learn to work together and navigate the perils of New York City and the hidden realms below in order to fulfill their destiny to become a team of heroes.

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The line-up of guest stars voicing these new mutants and bizarre villains includes:Lena Headey(Game of Thrones) as Big Mama, a gigantic spider mutant;John Michael Higgins(Pitch Perfect) as Warren Stone, a former news anchor turned mutant earthworm;Tom Kenny(SpongeBob SquarePants) as Albearto, a singing, birthday-loving rampaging robot;Sam RichardsonandTim Simons(Veep) as Muninn and Huginn, gargoyles who are never far from their master, Baron Draxum;John Rotten Lydon(Public Image Ltd ‘PiL’ and Sex Pistols) as Meat Sweats, a power-hungry mutant pig;Rhys Darby(Jumanji: Welcome to the Jungle) as Hypno-Potamus, a mutant magician/hippo; andJorge Gutierrez(El Tigre) as Ghostbear, a human pro-wrestler champion with a taste for cheating.

In addition, Rob Paulsen (Teenage Mutant Ninja Turtles) andMaurice LaMarche(Animaniacs) reunite behind the mic as Foot Lieutenant, the de-facto leader of the Foot Clan, and Foot Brute, the Foot Lieutenant’s right hand man.

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In the half-hour launch episode, “Mystic Mayhem,” the Turtles discover for the first time that they’re not the weirdest things in New York. Fans can watch a sneak peek of “Mystic Mayhem” on Friday, July 20th, at 9:30 p.m. (ET/PT) on Nickelodeon. Additional episodes will be available on the Nick App,Nick.com, and Nick On Demand.

Pictured (L-R): Nickelodeon’sRise of the Teenage Mutant Ninja Turtlesvillains Warren Stone, Meat Sweats, The Crab Brothers, Baron Draxum, Hypno-Potamus, and Repo Mantis.

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John Michael Higgins voices Warren Stone in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

Tom Kenny voices Albearto in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

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Lena Heady voices Big Mama in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

John Rotten Lydon voices Meat Sweats in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

Jorge Gutierrez voices Ghostbear in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

Sam Richardson voices Munnin in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

Tim Simons voices Huginn in Nickelodeon’sRise of the Teenage Mutant Ninja Turtles.

The series stars the voice talent of Omar Miller (Ballers) as Raph, a jagged-shelled snapping turtle; Ben Schwartz (Parks and Recreation) as Leo, a red-eared slider turtle; Josh Brener (Silicon Valley) as Donnie, a soft-shell turtle; Brandon Mychal Smith (You’re The Worst) as Mikey, a box turtle; Kat Graham (The Vampire Diaries) as April O’Neil, a street savvy native New Yorker; Eric Bauza (Teenage Mutant Ninja Turtles) as Splinter, father figure and sensei to the Turtles; and WWE SuperstarJohn Cenaas the villainous, Baron Draxum.

The new 26-episode series is co-executive produced by Andy Suriano (character designer,Samurai Jack) and Ant Ward (supervising producer,Teenage Mutant Ninja Turtles) at Nickelodeon in Burbank. Veteran animation industry voice actor Rob Paulsen is voice directing the series.

Viewers can visit theRise of the Teenage Mutant Ninja Turtlespage onNick.comandFacebookfor more information and follow @TMNT everywhere else for Turtle Power updates.